Cochrane · systematic review · CD011671
Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation
Tingle, SJ, Figueiredo, RS, Moir, JAG, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
9
No studies
1
Included studies
NR
No studies 1 · 10%Ungraded 0 · 0%Very low 1 · 10%Low 2 · 20%Moderate 0 · 0%High 6 · 60%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hypothermic machine perfusion versus static cold storage for deceased donor kidney transplantation
Population: deceased donor kidney transplantation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
DGF Hypothermic machine perfusion vs static cold storage | RR 0.77 [0.67, 0.9] | 14 studies · 2138 participants | High |
DGF: DCD group Hypothermic machine perfusion vs static cold storage | RR 0.75 [0.64, 0.87] | 7 studies · 772 participants | High |
DGF: DBD group Hypothermic machine perfusion vs static cold storage | RR 0.78 [0.65, 0.93] | 4 studies · 971 participants | High |
DGF: modern era studies Hypothermic machine perfusion vs static cold storage | RR 0.77 [0.66, 0.91] | 5 studies · 1355 participants | High |
DGF: pre‐2008 studies Hypothermic machine perfusion vs static cold storage | RR 0.78 [0.61, 0.99] | 9 studies · 783 participants | High |
One year graft survival Hypothermic machine perfusion vs static cold storage | no estimate extracted | NR | No studies |
PNF Hypothermic machine perfusion vs static cold storage | RR 0.88 [0.58, 1.33] | 7 studies · 1387 participants | High |
Duration of DGF Hypothermic machine perfusion vs static cold storage | no estimate extracted | 4 studies · 220 participants | Very low Downgraded: inconsistency |
One year patient survival Hypothermic machine perfusion vs static cold storage | RR 0.99 [0.95, 1.03] | 3 studies · 920 participants | Low Downgraded: inconsistency |
Treated acute rejection in the first year Hypothermic machine perfusion vs static cold storage | RR 0.66 [0.37, 1.17] | 2 studies · 248 participants | Low Downgraded: inconsistency |