Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Childhood Cancer

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Hyperfractionated radiotherapy vs radiotherapy

Overall survival · children and young adults with diffuse brainstem glioma

Hyperfractionated radiotherapy showed no clear difference in overall survival compared with conventional radiotherapy (low certainty).

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
HR 1.07 [0.75, 1.53]
1 study · 130 participants
Low

Hyperfractionated radiotherapy vs radiotherapy

Progression‐free survival · children and young adults with diffuse brainstem glioma

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperfractionated radiotherapy vs radiotherapy

Event‐free survival · children and young adults with diffuse brainstem glioma

Hyperfractionated radiotherapy showed no clear difference in event‐free survival compared with conventional radiotherapy (low certainty).

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
HR 1.26 [0.83, 1.9]
1 study · 130 participants
Low

Hyperfractionated radiotherapy vs radiotherapy

Quality of life · children and young adults with diffuse brainstem glioma

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperfractionated radiotherapy vs radiotherapy

Neurological response · children and young adults with diffuse brainstem glioma

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperfractionated radiotherapy vs radiotherapy

Radiological response defined as the number of participants with a reduction in tumour size > 50% · children and young adults with diffuse brainstem glioma

It is very uncertain whether hyperfractionated radiotherapy changes radiological response defined as the number of participants with a… compared with conventional radiotherapy (very low certainty).

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
RR 0.94 [0.54, 1.63]
1 study · 108 participants
Very low

Hyperfractionated radiotherapy vs radiotherapy

Toxicities · children and young adults with diffuse brainstem glioma

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 112 participants
Very low