Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%

Human deoxyribonuclease vs placebo

Clinical failure Number of children with no significant improvement in cough diary scores at two weeks (average of day 13 to 14) · children with primary (intrinsic) tracheomalacia

Human deoxyribonuclease showed no clear difference in clinical failure Number of children with no significant improvement… compared with placebo (low certainty).

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
OR 1.38 [0.37, 5.14]
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Cough · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Night time cough diary score (change from baseline) · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Night time VAS (change from baseline) · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Difficulty expectorating sputum score (change from baseline) · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

FVC (% predicted) Change from baseline · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low

Human deoxyribonuclease vs placebo

FEV1 · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low