What do systematic reviews say?

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

• Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes

  12 months
  Serum hs-CRP tested at one year; as loss to follow-up was almost 90%, data not considered useful for analysis (no usable estimate).
  1 study · 37 participants
  GRADE not reported

Vitamin D vs placebo or control

Meta-analysis of randomised trials of vitamin D supplementation for High density lipoprotein: WMD -0.14 (95% CI -0.99 to 0.71), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  WMD -0.14 [-0.99, 0.71]
  8 studies
  GRADE not reported

Low socioeconomic position and adverse behavioural factors vs Higher socioeconomic position and fewer adverse behaviours

In one 5-year longitudinal study, accumulation of low socioeconomic and behavioural factors was associated with greater periodontal disease progression and higher C-reactive protein; not pooled (ungraded).

• Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. 2016 All outcomes

  5-year follow-up · General adult population, Germany (Study of Health in Pomerania)
  no estimate extracted
  1 study · 3300 participants
  GRADE not reported