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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine, studies with lower risk of bias · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs midazolam

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).

1 finding from 1 review

High dose clonidine vs low dose clonidine

Number requiring additional analgesia required postoperatively ‐ moderate quality studies · patients with postoperative pain

High dose clonidine may leads to lower number requiring additional analgesia required postoperatively ‐… compared with low dose clonidine (low certainty).

1 finding from 1 review