Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews · Periodontology · All outcomes

No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Sites with attachment loss greater than 3 mm · Humans with salivary S. mutans measured

High salivary S. mutans was not associated with a clear difference in sites with attachment loss greater than 3 mm.

1 finding from 1 review

Salivary S. mutans level · Humans with salivary bacteria measured

Salivary F. nucleatum and Actinobacillus levels were not associated with a clear difference.

1 finding from 1 review

High salivary P. gingivalis (over 10^4 CFU/ml) · adults

Periodontitis was associated with higher odds of detectable high-level salivary P. gingivalis (OR 3.38).

1 finding from 1 review

Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomes
Salivary/plaque microbiology samples from case-control studies · Overall
OR 3.38 [1.46, 7.83]
2 studies
GRADE not reported

High salivary S. mutans (over 10^4 CFU/ml) · adults

Salivary S. mutans showed a non-significant declining trend with periodontitis (OR 0.82).

1 finding from 1 review

Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomes
Salivary/plaque microbiology samples from case-control studies · Overall
OR 0.82 [0.44, 1.51]
2 studies
GRADE not reported

High salivary S. mutans (over 10^4 CFU/ml) · Periodontitis patients

High-level S. mutans did not change significantly after periodontal therapy (OR 1.54).

1 finding from 1 review

Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomes
Post-treatment · Salivary/plaque microbiology samples from case-control studies · Overall
OR 1.54 [0.47, 5.02]
3 studies
GRADE not reported

Serum high-sensitivity C-reactive protein (hs-CRP) · Patients with cardiovascular disease and chronic periodontitis

1 finding from 1 review

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes
12 months
Serum hs-CRP tested at one year; as loss to follow-up was almost 90%, data not considered useful for analysis (no usable estimate).
1 study · 37 participants
GRADE not reported