Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pain, Palliative and Supportive Care

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Ambulation · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in ambulation compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
RR 1.08 [0.81, 1.45]
3 studies · 105 participants
Low

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Survival (long term) Over two years · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in survival (long term) Over two years compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
RR 1.11 [0.24, 5.05]
1 study · 57 participants
Low

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Pain reduction · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in pain reduction compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
RR 0.86 [0.62, 1.2]
1 study · 25 participants
Low

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Urinary continence One week after treatment · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in urinary continence One week after treatment compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
RR 1.18 [0.66, 2.13]
1 study · 34 participants
Low

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Local recurrence · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
RR 8.02 [1.03, 62.37]
2 studies · 77 participants
Moderate

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Quality of life · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found