Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

71 questions · 80 findings · 6 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 17 · 21.3%GRADE not reported 0 · 0%Very low 27 · 33.8%Low 21 · 26.3%Moderate 13 · 16.3%High 2 · 2.5%

Heparin prophylaxis vs no prophylaxis

All‐cause mortality

Heparin prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

2 findings from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

All‐cause mortality (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

Low‐molecular‐weight heparin (LMWH) showed no clear difference in all‐cause mortality (up to 3 months) compared with vitamin K antagonist (VKA) (low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Symptomatic catheter‐related thrombosis (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes symptomatic catheter‐related thrombosis (up to 3 months) compared with vitamin K antagonist (VKA) (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Symptomatic catheter‐related thrombosis measured as asymptomatic catheter‐related thrombosis (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes symptomatic catheter‐related thrombosis measured as asymptomatic… compared with vitamin K antagonist (VKA) (very low certainty).

1 finding from 1 review