Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 3 reviews · Haematology · Headline outcomes only

No studies found 0 · 0%GRADE not reported 1 · 7.7%Very low 1 · 7.7%Low 11 · 84.6%Moderate 0 · 0%High 0 · 0%

Mycophenolate mofetil vs methotrexate

Prevention of acute GVHD grade II to IV · people receiving allogeneic hematopoietic stem cell transplantation

It is very uncertain whether mycophenolate mofetil changes prevention of acute GVHD grade II to IV compared with methotrexate (very low certainty).

1 finding from 1 review

Mycophenolate mofetil vs methotrexate

Incidence of narcotic use for pain control · people receiving allogeneic hematopoietic stem cell transplantation

Mycophenolate mofetil may leads to lower incidence of narcotic use for pain control compared with methotrexate (low certainty).

1 finding from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with best available therapy (low certainty).

1 finding from 1 review

Ruxolitinib vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib may leads to higher safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with placebo (low certainty).

1 finding from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): anemia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): anemia Grades 3 or 4 according… compared with best available therapy (low certainty).

1 finding from 1 review