Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

HT FET vs HT + GnRHa FET

Ongoing pregnancy · women with primary or secondary subfertility

It is very uncertain whether HT FET changes ongoing pregnancy rate per woman compared with HT + GnRHa FET (very low certainty).

1 finding from 1 review

Routine fetal movement counting vs mixed or undefined fetal movement counting

Maternal‐fetal attachment · Pregnant women who had reached the gestational age of fetal viability

Routine fetal movement counting showed no clear difference in maternal‐fetal attachment compared with mixed or undefined fetal movement counting (low certainty).

1 finding from 1 review

Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography (CTG) vs CTG alone

Fetal blood sampling ‐ ST analysis · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring

Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… leads to lower fetal blood sampling ‐ ST analysis compared with CTG alone (high certainty).

1 finding from 1 review

Routine fetal movement counting vs mixed or undefined fetal movement counting

Number of antenatal hospital admissions · Pregnant women who had reached the gestational age of fetal viability

Routine fetal movement counting showed no clear difference in antenatal hospital admission rate per cluster (mean) compared with mixed or undefined fetal movement counting (low certainty).

1 finding from 1 review

Routine fetal movement counting vs mixed or undefined fetal movement counting

Low birthweight (< 2500 g or < 10th centile) · Pregnant women who had reached the gestational age of fetal viability

Routine fetal movement counting showed no clear difference in low birthweight (< 2500 g or < 10th centile) compared with mixed or undefined fetal movement counting (low certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Doppler vs routine Pinard (outcomes

Caesarean section for fetal distress and/or fetal acidosis · women in established labour and their babies.

Intermittent ausculation of fetal heart rate in labour for fetal… probably leads to higher caesarean section for fetal distress and/or fetal acidosis compared with routine Pinard (outcomes (moderate certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intensive Pinard vs routine Pinard (outcomes

Caesarean section for fetal distress and/or fetal acidosis · women in established labour and their babies.

Intermittent ausculation of fetal heart rate in labour for fetal… showed no clear difference in caesarean section for fetal distress and/or fetal acidosis compared with routine Pinard (outcomes (low certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intermittent electronic fetal monitoring (CTG) vs routine Pinard (outcomes

Caesarean section for fetal distress and/or fetal acidosis · women in established labour and their babies.

Intermittent ausculation of fetal heart rate in labour for fetal… probably leads to higher caesarean section for fetal distress and/or fetal acidosis compared with routine Pinard (outcomes (moderate certainty).

1 finding from 1 review

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham (low certainty).

1 finding from 1 review