Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

294 questions · 295 findings · 16 reviews · Schizophrenia

No studies found 79 · 26.8%GRADE not reported 32 · 10.8%Very low 99 · 33.6%Low 55 · 18.6%Moderate 17 · 5.8%High 13 · 4.4%

HALOPERIDOL vs COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE

Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Tranquilisation or asleep ‐ not asleep by 3 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep ‐ not asleep by 3 hours compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Repeated need for rapid tranquillisation ‐ needing additional injection during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for rapid tranquillisation ‐ needing additional… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Global outcome: no overall improvement ‐ at 30 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: specific ‐ dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia (only reported if occurred in… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ hypertonia/rigidity (only reported if… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: c. HALOPERIDOL + MIDAZOLAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (very low certainty).

1 finding from 1 review