Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

41 questions · 42 findings · 8 reviews · Headline outcomes only

No studies found 10 · 23.8%GRADE not reported 0 · 0%Very low 18 · 42.9%Low 5 · 11.9%Moderate 7 · 16.7%High 2 · 4.8%

Glutamine‐supplemented nutrition vs non‐supplemented nutrition

Short‐term mortality (within hospital stay or closest to one month) · critically ill patients or receiving major surgery

Glutamine‐supplemented nutrition showed no clear difference in short‐term mortality (within hospital stay or closest to one month) compared with non‐supplemented nutrition (low certainty).

1 finding from 1 review

Glutamine‐supplemented nutrition vs non‐supplemented nutrition

Long‐term mortality (closest to six month) · critically ill patients or receiving major surgery

Glutamine‐supplemented nutrition showed no clear difference in long‐term mortality (closest to six month) compared with non‐supplemented nutrition (moderate certainty).

1 finding from 1 review

Glutamine vs placebo

Incidence of hepatic veno‐occlusive disease ( · People undergoing stem cell transplant with haematological malignancies

It is very uncertain whether summary of findings: Glutamine changes incidence of hepatic veno‐occlusive disease ( compared with placebo (very low certainty).

1 finding from 1 review

Glutamine vs placebo

All‐cause mortality at 100 days post‐transplant · People undergoing stem cell transplant with haematological malignancies

It is very uncertain whether summary of findings: Glutamine changes all‐cause mortality at 100 days post‐transplant ( compared with placebo (very low certainty).

1 finding from 1 review

Glutamine vs placebo

Mortality attributable to hepatic veno‐occlusive disease ( · People undergoing stem cell transplant with haematological malignancies

It is very uncertain whether summary of findings: Glutamine changes mortality attributable to hepatic veno‐occlusive disease ( compared with placebo (very low certainty).

1 finding from 1 review