Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania
Glutamate modulators probably leads to higher treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (moderate certainty).
1 finding from 1 review
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review
Withdrawals due to adverse events · adults with trichotillomania
1 finding from 1 review
Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children and adolescents with trichotillomania
Glutamate modulators showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).
1 finding from 1 review
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children and adolescents with trichotillomania
1 finding from 1 review
Dropouts due to adverse events · children and adolescents with trichotillomania
Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder
Ketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).
4 findings from 1 review
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low
OR 4.88 [0.78, 30.29]
1 study · 29 participants
Very low
OR 5.33 [1.02, 27.76]
1 study · 29 participants
Very low
Show 1 more finding
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: dropouts due to adverse effects compared with placebo (low certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depression rating scale score · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes acceptability: total dropouts compared with placebo (very low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
N‐acetylcysteine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).
1 finding from 1 review