Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).
The review found no eligible studies for this question.
Metformin combined with clomiphene citrate probably leads to higher ovulation rate per woman compared with clomiphene citrate alone (moderate certainty).
Metformin combined with clomiphene citrate may leads to higher miscarriage rate per woman compared with clomiphene citrate alone (low certainty).
It is very uncertain whether metformin changes live birth rate per woman Participants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).
It is very uncertain whether metformin changes live birth rate per woman Participants with BMI ≥ 30 kg/m2a compared with clomiphene citrate (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether metformin changes clinical pregnancy rate per woman Participants with BMI < 30 kg/m2… compared with clomiphene citrate (very low certainty).
It is very uncertain whether metformin changes clinical pregnancy rate per woman Participants with BMI ≥ 30 kg/m2a compared with clomiphene citrate (very low certainty).
The review found no eligible studies for this question.
Metformin showed no clear difference in ovulation rate per woman Participants with BMI < 30 kg/m2b compared with clomiphene citrate (low certainty).
Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).
Metformin may leads to lower ovulation rate per woman Participants with BMI ≥ 30 kg/m2b compared with clomiphene citrate (low certainty).
It is very uncertain whether metformin changes miscarriage rate per woman compared with clomiphene citrate (very low certainty).
Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).
Metformin may leads to higher menstrual frequency per woman compared with placebo or no treatment (low certainty).
Metformin probably leads to higher ovulation rate per woman compared with placebo or no treatment (moderate certainty).
Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).
Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).
Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).