What do systematic reviews say?

Gestrinone vs danazol

It is very uncertain whether gestrinone changes side effects: hot flushes compared with danazol (very low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.79 [0.5, 1.26]
  2 studies · 302 participants
  Very low

Gestrinone vs danazol

Gestrinone showed no clear difference in side effects: acne compared with danazol (low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 1.45 [0.9, 2.33]
  2 studies · 302 participants
  Low

Gestrinone vs leuprolin

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Gestrinone vs leuprolin

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 52 participants
  Low

Gestrinone vs leuprolin

Gestrinone may leads to lower amenorrhoea compared with leuprolin (low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.04 [0.01, 0.38]
  1 study · 49 participants
  Low

Gestrinone vs leuprolin

Gestrinone may leads to higher spotting or bleeding compared with leuprolin (low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 22.92 [2.64, 198.66]
  1 study · 49 participants
  Low

Gestrinone vs leuprolin

Gestrinone may leads to lower side effects: hot flushes compared with leuprolin (low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.2 [0.06, 0.63]
  1 study · 55 participants
  Low

Gestrinone vs danazol

It is very uncertain whether gestrinone changes pelvic pain: none or mild compared with danazol (very low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.71 [0.33, 1.56]
  2 studies · 230 participants
  Very low

Gestrinone vs danazol

It is very uncertain whether gestrinone changes dysmenorrhoea: none or mild compared with danazol (very low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.72 [0.39, 1.33]
  2 studies · 214 participants
  Very low

Gestrinone vs danazol

It is very uncertain whether gestrinone changes dyspareunia: none or mild compared with danazol (very low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.83 [0.37, 1.86]
  2 studies · 222 participants
  Very low

Gestrinone vs danazol

It is very uncertain whether gestrinone changes side effects: hirsutism compared with danazol (very low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 2.63 [1.6, 4.32]
  2 studies · 302 participants
  Very low

Gestrinone vs danazol

Gestrinone may leads to lower decreased breast size compared with danazol (low certainty).

• Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
  OR 0.62 [0.38, 0.98]
  2 studies · 302 participants
  Low

Effect of GnRHas vs other hormonal treatment on bone mineral density

• Gonadotropin‐releasing hormone analogues for endometriosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 41 participants
  Very low
• Gonadotropin‐releasing hormone analogues for endometriosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 41 participants
  Very low