Findings

What do systematic reviews say?

17 questions · 17 findings · 3 reviews · Common Mental Disorders

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No studies found 2 · 11.8%GRADE not reported 0 · 0%Very low 3 · 17.6%Low 11 · 64.7%Moderate 1 · 5.9%High 0 · 0%

Cell signal transducers vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Glutamate modulators vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Moderate

Glutamate modulators vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children and adolescents with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low

Opioid antagonists vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Low

Selective serotonin reuptake inhibitors vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 6 participants
Low

Antipsychotics vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania

1 finding from 1 review

Pharmacotherapy for trichotillomania 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Low

Therapist‐supported ICBT vs face‐to‐face CBT

Anxiety · adults with anxiety disorders

1 finding from 1 review

Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 343 participants
Low

Therapist‐supported ICBT vs waiting list, attention, information, or online discussion group only control

Anxiety · patients with anxiety disorders

1 finding from 1 review

Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 1496 participants
Low

Therapist‐supported ICBT vs unguided CBT

Anxiety · patients with anxiety disorders

1 finding from 1 review

Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 138 participants
Very low

Fluoxetine vs light therapy

Remission (response plus end score 8 or less) · adults with seasonal affective disorder

It is very uncertain whether fluoxetine changes remission (response plus end score 8 or less) compared with light therapy (very low certainty).

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
RR 0.81 [0.39, 1.71]
2 studies · 136 participants
Very low

Fluoxetine vs light therapy

Speed of onset of response · adults with seasonal affective disorder

The review found no eligible studies for this question.

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fluoxetine vs light therapy

Adverse events ‐ treatment emergent · adults with seasonal affective disorder

Fluoxetine showed no clear difference in adverse events (at least 1 treatment‐emergent adverse event) compared with light therapy (low certainty).

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
RR 0.97 [0.78, 1.22]
1 study · 96 participants
Low

Fluoxetine vs light therapy

Response (> 50% improvement on 24‐item HAM‐D SIGH‐SAD) · adults with seasonal affective disorder

Fluoxetine showed no clear difference in response (> 50% improvement on 24‐item HAM‐D SIGH‐SAD) compared with light therapy (low certainty).

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
RR 0.98 [0.77, 1.24]
2 studies · 136 participants
Low

Fluoxetine vs light therapy

Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · adults with seasonal affective disorder

The review found no eligible studies for this question.

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fluoxetine vs light therapy

Quality of life (SF‐20 & Q‐LES‐Q) Eight weeks · adults with seasonal affective disorder

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low