Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 1 reviews · Urology

No studies found 6 · 28.6%GRADE not reported 0 · 0%Very low 6 · 28.6%Low 9 · 42.9%Moderate 0 · 0%High 0 · 0%

Gemcitabine vs mitomycin

Grade III–V adverse events (local adverse events which result in delay intravesical treatment were regarded as Grade III–V complications) · patients with non‐muscle invasive bladder cancer

It is very uncertain whether gemcitabine changes grade III–V adverse events (local adverse events which result in… compared with mitomycin (very low certainty).

1 finding from 1 review

Gemcitabine vs mitomycin

Grade I or II adverse events (local adverse events which did not result in delay intravesical treatment) · patients with non‐muscle invasive bladder cancer

Gemcitabine may leads to lower grade I or II adverse events (local adverse events which did not… compared with mitomycin (low certainty).

1 finding from 1 review

Gemcitabine vs BCG

Time to recurrence · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

Gemcitabine may leads to lower time to recurrence compared with BCG (low certainty).

1 finding from 1 review

Gemcitabine vs BCG

Time to progression · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

Gemcitabine may leads to lower time to progression compared with BCG (low certainty).

1 finding from 1 review

Gemcitabine vs BCG

Adverse events grade 3 to 5 Range of · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

It is very uncertain whether gemcitabine changes grade III–V adverse events compared with BCG (very low certainty).

1 finding from 1 review

Gemcitabine vs BCG

Time to death from bladder cancer · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

It is very uncertain whether gemcitabine changes time to death from bladder cancer compared with BCG (very low certainty).

1 finding from 1 review

Gemcitabine vs BCG

Time to death from any cause · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

The review found no eligible studies for this question.

1 finding from 1 review

Gemcitabine vs BCG

Adverse events: grade 1 to 2 · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

It is very uncertain whether gemcitabine changes grade I or II adverse events compared with BCG (very low certainty).

1 finding from 1 review

Gemcitabine vs BCG

Disease‐specific quality of life · participants with recurrent (1‐course BCG failure) high‐risk non‐muscle invasive bladder cancer (49 men, 31 women)Country: Italy

The review found no eligible studies for this question.

1 finding from 1 review

Gemcitabine vs Normal saline

Overall survival (absolute effect size estimates based on survival rate at 12 months) · patients with non‐muscle invasive bladder cancer

It is very uncertain whether gemcitabine changes time to death from any cause (absolute effect size estimates based… compared with saline (very low certainty).

1 finding from 1 review