Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

23 questions · 23 findings · 2 reviews

No studies found 4 · 17.4%GRADE not reported 0 · 0%Very low 0 · 0%Low 11 · 47.8%Moderate 8 · 34.8%High 0 · 0%

Extended prophylaxis vs another VTE extended prophylaxis

Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · patients with unprovoked venous thromboembolism

VTE extended prophylaxis showed no clear difference in clinically relevant non‐major bleedingf compared with another VTE extended prophylaxis (moderate certainty).

1 finding from 1 review

Extended prophylaxis vs placebo

Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · patients with unprovoked venous thromboembolism

Extended prophylaxis showed no clear difference in clinically relevant non‐major bleedingh compared with placebo (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks may leads to lower HIV transmission at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks showed no clear difference in infants with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review