Findings

What do systematic reviews say?

9 questions · 9 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 9 · 100%Moderate 0 · 0%High 0 · 0%

Intervention not reported

Death from any cause prior to hospital discharge · Neonates with PPHN

The intervention showed no clear difference in death from any cause prior to hospital discharge (low certainty).

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
RR 0.2 [0.02, 1.77]
37 participants
Low

Intervention not reported

Percentage of infants that showed improvement in OI by at least 20% by the end of therapy · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
39 participants
Low

Intervention not reported

Adverse neurological outcomes at six months of age · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low

Intervention not reported

Cerebral Palsy · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low

Intervention not reported

Deafness · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low

Intervention not reported

Need for ECMO prior to discharge · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
21 participants
Low

Intervention not reported

Total duration of mechanical ventilation (days) · Neonates with PPHN

The intervention showed no clear difference in total duration of mechanical ventilation (days) (low certainty).

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low

Intervention not reported

Duration of iNO therapy (days) · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
21 participants
Low

Intervention not reported

Total duration of mechanical ventilation (days) · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
21 participants
Low