Meters change from baseline in 6MWD · pulmonary arterial hypertension
1 finding from 1 review
Proportion of participants with improved functional class mean duration of study 16.8 weeks · pulmonary arterial hypertension
Endothelin receptor antagonists probably leads to higher proportion of participants with improved functional class mean… compared with placebo (moderate certainty).
1 finding from 1 review
Change from baseline in BDI mean duration of study 14.3 weeks · pulmonary arterial hypertension
1 finding from 1 review
Mortality mean duration of study 30.2 weeks · pulmonary arterial hypertension
Endothelin receptor antagonists showed no clear difference in mortality mean duration of study 30.2 weeks compared with placebo (low certainty).
1 finding from 1 review
Change from baseline in mean PAP (mmHg) mean duration of study 17.1 weeks · pulmonary arterial hypertension
1 finding from 1 review
Change from baseline in PVR (dyn/s/cm5) mean duration of study 15.7 weeks · pulmonary arterial hypertension
1 finding from 1 review
Hepatic toxicity mean duration of study 25 weeks · pulmonary arterial hypertension
Endothelin receptor antagonists showed no clear difference in hepatic toxicity mean duration of study 25 weeks compared with placebo (moderate certainty).
1 finding from 1 review
Intervention not reported
Death from any cause prior to hospital discharge · Neonates with PPHN
The intervention showed no clear difference in death from any cause prior to hospital discharge (low certainty).
1 finding from 1 review
RR 0.2 [0.02, 1.77]
37 participants
Low
Intervention not reported
Percentage of infants that showed improvement in OI by at least 20% by the end of therapy · Neonates with PPHN
1 finding from 1 review
no estimate extracted
39 participants
Low
Intervention not reported
Adverse neurological outcomes at six months of age · Neonates with PPHN
1 finding from 1 review
no estimate extracted
37 participants
Low
Intervention not reported
Cerebral Palsy · Neonates with PPHN
1 finding from 1 review
no estimate extracted
37 participants
Low
Intervention not reported
Deafness · Neonates with PPHN
1 finding from 1 review
no estimate extracted
37 participants
Low
Intervention not reported
Need for ECMO prior to discharge · Neonates with PPHN
1 finding from 1 review
no estimate extracted
21 participants
Low
Intervention not reported
Total duration of mechanical ventilation (days) · Neonates with PPHN
The intervention showed no clear difference in total duration of mechanical ventilation (days) (low certainty).
1 finding from 1 review
no estimate extracted
37 participants
Low
Intervention not reported
Duration of iNO therapy (days) · Neonates with PPHN
1 finding from 1 review
no estimate extracted
21 participants
Low
Intervention not reported
Total duration of mechanical ventilation (days) · Neonates with PPHN
1 finding from 1 review
no estimate extracted
21 participants
Low