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What do systematic reviews say?

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Evidence found and GRADE certainty

153 questions · 155 findings · 33 reviews · Gut · Headline outcomes only

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No studies found 40 · 25.8%GRADE not reported 2 · 1.3%Very low 31 · 20%Low 42 · 27.1%Moderate 34 · 21.9%High 6 · 3.9%

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Endoscopic haemostatic treatment at index endoscopy · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment probably leads to lower endoscopic haemostatic treatment at index endoscopy compared with H2RA, placebo or no treatment (moderate certainty).

1 finding from 1 review

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

Treatment failure Feeding interruption, blocking or leakage of the tube, non‐adherence · adult patients with swallowing disturbances

Percutaneous endoscopic gastrostomy may leads to lower treatment failure Feeding interruption, blocking or leakage of the… compared with nasogastric tube feeding (low certainty).

1 finding from 1 review

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

Mortality irrespective of · adult patients with swallowing disturbances

It is very uncertain whether percutaneous endoscopic gastrostomy changes mortality irrespective of compared with nasogastric tube feeding (very low certainty).

1 finding from 1 review

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

Adverse events irrespective of · adult patients with swallowing disturbances

Percutaneous endoscopic gastrostomy showed no clear difference in adverse events irrespective of compared with nasogastric tube feeding (moderate certainty).

1 finding from 1 review