Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 10 findings · 2 reviews · Neonatal

No studies found 2 · 20%GRADE not reported 0 · 0%Very low 1 · 10%Low 1 · 10%Moderate 2 · 20%High 4 · 40%

High‐dose vs standard‐dose strategies

Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants with or at risk for apnea of prematurity

It is very uncertain whether high‐dose changes side effects (tachycardia, agitation or feed intolerance) leading to… compared with standard‐dose strategies (very low certainty).

3 findings from 1 review