Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · All outcomes

No studies found 0 · 0%GRADE not reported 2 · 66.7%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Adverse effects (loose stools, diarrhoea) · Infants (primary teeth; baseline about 9 to 15 months)

1 finding from 1 review

Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes
12 months
Adverse effects were not reported in a usable format, but the reported rates of loose stools and diarrhoea were very similar between groups. There were no serious adverse effects during the study. Milgrom 2009.
1 study · 94 participants
GRADE not reported

Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
14 to 36 months
Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
1 study · 220 participants
Very low

Adverse effects · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)

1 finding from 1 review

Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
One study reported adverse effects (Warkentin 2002). Twenty patients allocated to receive high dose valaciclovir reported adverse effects (42%); for the low dose group this number was 27 (52%). Adverse effects were…
1 study · 100 participants
GRADE not reported