Findings

What do systematic reviews say?

88 questions · 88 findings · 11 reviews · Epilepsy

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No studies found 3 · 3.4%GRADE not reported 0 · 0%Very low 2 · 2.3%Low 30 · 34.1%Moderate 31 · 35.2%High 22 · 25%

Omega‐3 (with risperidone and previous ASM) vs risperidone and previous ASM only

Proportion of individuals withdrawing from treatment · people with ADHD and epilepsy

Omega‐3 (with risperidone and previous ASM) showed no clear difference in proportion of individuals withdrawing from treatment compared with risperidone and previous ASM only (low certainty).

1 finding from 1 review

Stimulant and non‐stimulant drug therapy for people with attention deficit hyperactivity disorder and epilepsy 2022 · Cochrane Headline outcomes only
RR 0.65 [0.12, 3.59]
1 study · 61 participants
Low

Topiramate vs placebo

Proportion of participants who experienced at least one AE and individual AEs · people with juvenile myoclonic epilepsy

1 finding from 1 review

Topiramate for juvenile myoclonic epilepsy 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Topiramate vs valproate

Proportion of participants who experienced at least one AE and individual AEs · people with juvenile myoclonic epilepsy

1 finding from 1 review

Topiramate for juvenile myoclonic epilepsy 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 61 participants
Very low

Early vs late AED withdrawal

Seizure relapse rate by time of withdrawal · individuals with epilepsy in remission

Early may leads to higher seizure relapse rate by time of withdrawal compared with late AED withdrawal (low certainty).

1 finding from 1 review

Early versus late antiepileptic drug withdrawal for people with epilepsy in remission 2015 · Cochrane Headline outcomes only
RR 1.34 [1.13, 1.59]
5 studies · 924 participants
Low

Early vs late AED withdrawal

Seizure relapse rate in people with partial epilepsy by time of withdrawal · individuals with epilepsy in remission

Early showed no clear difference in seizure relapse rate in people with partial epilepsy by time of… compared with late AED withdrawal (low certainty).

1 finding from 1 review

Early versus late antiepileptic drug withdrawal for people with epilepsy in remission 2015 · Cochrane Headline outcomes only
RR 1.51 [0.97, 2.35]
2 studies · 180 participants
Low

Intervention not reported

Any reason · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 520 participants
High

Intervention not reported

Comparison (reference treatment) · adults and children with focal seizures

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Carbamazepine · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 525 participants
High

Intervention not reported

Comparison (reference treatment) · adults and children with focal seizures

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Lamotrigine · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 907 participants
High

Intervention not reported

Comparison (reference treatment) · adults and children with generalised seizures*

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Sodium valproate · adults and children with generalised seizures*

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 412 participants
High

Intervention not reported

Adverse events · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 520 participants
High

Intervention not reported

Lack of efficacy · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 388 participants
High

Intervention not reported

Any reason · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 2203 participants
High

Intervention not reported

Adverse events · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 2203 participants
High

Intervention not reported

Lack of efficacy · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2098 participants
High

Intervention not reported

Any reason · adults and children with generalised tonic‐clonic seizures with or without other seizure types

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 405 participants
High

Intervention not reported

Adverse events · adults and children with generalised tonic‐clonic seizures with or without other seizure types

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 117 participants
High

Intervention not reported

Lack of efficacy · adults and children with generalised tonic‐clonic seizures with or without other seizure types

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 405 participants
High