Cochrane · systematic review · CD001902
Early versus late antiepileptic drug withdrawal for people with epilepsy in remission
Strozzi, I, Nolan, SJ, Sperling, MR, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early versus late AED withdrawal for people with epilepsy in remission
Population: individuals with epilepsy in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Seizure relapse rate by time of withdrawal Early vs late AED withdrawal | RR 1.34 [1.13, 1.59] | 5 studies · 924 participants | Low Downgraded: risk of bias |
Seizure relapse rate in people with partial epilepsy by time of withdrawal Early vs late AED withdrawal | RR 1.51 [0.97, 2.35] | 2 studies · 180 participants | Low Downgraded: risk of bias, indirectness |
Abnormal versus normal EEG for people with epilepsy in remission
Population: people with epilepsy in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Seizure relapse rate by EEG findings Abnormal vs normal EEG | RR 1.44 [1.13, 1.83] | 2 studies · 618 participants | Low Downgraded: risk of bias |