Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 60%High 2 · 40%

All‐cause mortality · adults in sinus rhythm after cardioversion of atrial fibrillation

Dronedarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 0.86 [0.68, 1.09]
3 studies · 6071 participants
High

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Dronedarone probably leads to higher withdrawals due to adverse effects compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.58 [1.34, 1.85]
3 studies · 6071 participants
Moderate

Proarrhythmia · adults in sinus rhythm after cardioversion of atrial fibrillation

Dronedarone showed no clear difference in proarrhythmia compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.95 [0.77, 4.98]
2 studies · 5872 participants
Moderate

Stroke · adults in sinus rhythm after cardioversion of atrial fibrillation

Dronedarone leads to lower stroke compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 0.66 [0.47, 0.95]
2 studies · 5872 participants
High

Recurrence of atrial fibrillation · adults in sinus rhythm after cardioversion of atrial fibrillation

Dronedarone probably leads to lower recurrence of atrial fibrillation compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 0.85 [0.8, 0.91]
2 studies · 1443 participants
Moderate