Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%

Time to death from prostate cancerMedian · clinically localized and locally advanced prostate cancer

Dose‐escalated RT showed no clear difference in time to death from prostate cancer compared with conventional dose RT (moderate certainty).

1 finding from 1 review

Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer 2023 · Cochrane Headline outcomes only
HR 0.83 [0.66, 1.04]
8 studies · 5231 participants
Moderate

Severe RT toxicity (grade ≥ 3) · clinically localized and locally advanced prostate cancer

Dose‐escalated RT probably leads to higher severe RT toxicity (grade ≥ 3) compared with conventional dose RT (moderate certainty).

1 finding from 1 review

Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer 2023 · Cochrane Headline outcomes only
RR 1.72 [1.32, 2.25]
8 studies · 4992 participants
Moderate

Time to death from any cause · clinically localized and locally advanced prostate cancer

Dose‐escalated RT showed no clear difference in time to death from any cause compared with conventional dose RT (moderate certainty).

1 finding from 1 review

Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer 2023 · Cochrane Headline outcomes only
HR 0.98 [0.89, 1.09]
9 studies · 5437 participants
Moderate

Time to distant metastasis · clinically localized and locally advanced prostate cancer

Dose‐escalated RT showed no clear difference in time to distant metastasis compared with conventional dose RT (moderate certainty).

1 finding from 1 review

Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer 2023 · Cochrane Headline outcomes only
HR 0.83 [0.57, 1.22]
7 studies · 3499 participants
Moderate

Overall RT toxicity (grade ≥ 1) · clinically localized and locally advanced prostate cancer

Dose‐escalated RT may leads to higher overall RT toxicity (grade ≥ 1) compared with conventional dose RT (low certainty).

1 finding from 1 review

Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer 2023 · Cochrane Headline outcomes only
RR 1.27 [1.04, 1.55]
7 studies · 4328 participants
Low

Quality of life · clinically localized and locally advanced prostate cancer

1 finding from 1 review

Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 300 participants
Moderate