Cochrane · systematic review · CD012817
Dose‐escalated radiotherapy for clinically localized and locally advanced prostate cancer
Kim, S, Kong, JH, Lee, Y, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Dose‐escalated RT compared to conventional dose RT for clinically localized and locally advanced prostate cancer
Population: clinically localized and locally advanced prostate cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to death from prostate cancer Dose‐escalated RT vs conventional dose RT | HR 0.83 [0.66, 1.04] | 8 studies · 5231 participants | Moderate Downgraded: risk of bias, imprecision |
Severe RT toxicity (grade ≥ 3) Dose‐escalated RT vs conventional dose RT | RR 1.72 [1.32, 2.25] | 8 studies · 4992 participants | Moderate Downgraded: risk of bias, imprecision |
Time to death from any cause Dose‐escalated RT vs conventional dose RT | HR 0.98 [0.89, 1.09] | 9 studies · 5437 participants | Moderate Downgraded: risk of bias, imprecision |
Time to distant metastasis Dose‐escalated RT vs conventional dose RT | HR 0.83 [0.57, 1.22] | 7 studies · 3499 participants | Moderate Downgraded: risk of bias, imprecision |
Overall RT toxicity (grade ≥ 1) Dose‐escalated RT vs conventional dose RT | RR 1.27 [1.04, 1.55] | 7 studies · 4328 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Dose‐escalated RT vs conventional dose RT | no estimate extracted | 1 study · 300 participants | Moderate Downgraded: risk of bias, imprecision |