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Evidence found and GRADE certainty

46 questions · 48 findings · 4 reviews

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No studies found 3 · 6.3%GRADE not reported 0 · 0%Very low 7 · 14.6%Low 3 · 6.3%Moderate 32 · 66.7%High 3 · 6.3%

Donepezil 23 mg/day vs donepezil 10 mg/day

Clinician‐rated global impression test (improved compared with baseline assessed using CIBIC‐plus at 24 weeks) · people with Alzheimer's disease

Donepezil 23 mg/day showed no clear difference in clinician‐rated global impression test (improved compared with… compared with donepezil 10 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 23 mg/day vs donepezil 10 mg/day

Secondary outcome: acceptability of treatment · people with Alzheimer's disease

Donepezil 23 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with donepezil 10 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 23 mg/day vs donepezil 10 mg/day

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 23 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with donepezil 10 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Clinician‐rated global impression test (improved compared with baseline assessed using CIBIC‐plus at 24 weeks) · people with Alzheimer's disease

Donepezil 10 mg/day showed no clear difference in clinician‐rated global impression test (improved compared with… compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Secondary outcome: acceptability of treatment · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review