Findings

What do systematic reviews say?

139 questions · 147 findings · 16 reviews · Headline outcomes only

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No studies found 21 · 14.3%GRADE not reported 4 · 2.7%Very low 26 · 17.7%Low 61 · 41.5%Moderate 29 · 19.7%High 6 · 4.1%

Dexamethasone vs control

Postoperative wound or systemic infection · participants undergoing surgery

Dexamethasone showed no clear difference in postoperative wound or systemic infection compared with control (moderate certainty).

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
OR 1.01 [0.8, 1.27]
26 studies · 4603 participants
Moderate

Dexamethasone vs control

Delayed wound healing · participants undergoing surgery

Dexamethasone showed no clear difference in delayed wound healing compared with control (low certainty).

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
OR 0.99 [0.28, 3.43]
8 studies · 642 participants
Low

Dexamethasone vs control

Glycaemic response ‐ change from baseline to 2 to 12 hours postoperatively in patients without diabetes · participants undergoing surgery

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 595 participants
Low

Dexamethasone vs control

Glycaemic response ‐ change from baseline to 10 to 24 hours after surgery in patients with diabetes · participants undergoing surgery

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 74 participants
Very low

Dexamethasone vs betamethasone – maternal outcomes

Death · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs betamethasone – child outcomes

Neurodevelopmental disability · women at risk of preterm birth

Dexamethasone showed no clear difference in neurodevelopmental disability at compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 1.02 [0.85, 1.22]
2 studies · 1151 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Visual impairment · women at risk of preterm birth

Dexamethasone showed no clear difference in visual impairment compared with betamethasone – child outcomes (low certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.33 [0.01, 8.15]
1 study · 1227 participants
Low

Dexamethasone vs betamethasone – child outcomes

Hearing impairment · women at risk of preterm birth

Dexamethasone showed no clear difference in hearing impairment compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 1.16 [0.63, 2.16]
1 study · 1227 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Developmental delay –motor (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in developmental delay –motor (mild, moderate or severe) compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.89 [0.66, 1.2]
1 study · 1166 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Intellectual impairment: developmental delay – cognitive or language (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in intellectual impairment: developmental delay – cognitive or language… compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.97 [0.79, 1.2]
1 study · 1161 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Cerebral palsy · women at risk of preterm birth

Dexamethasone showed no clear difference in cerebral palsy compared with betamethasone – child outcomes (low certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 2.5 [0.97, 6.39]
1 study · 1223 participants
Low

Dexamethasone vs betamethasone – maternal outcomes

Chorioamnionitis · women at risk of preterm birth

Dexamethasone showed no clear difference in chorioamnionitis compared with betamethasone – maternal outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.71 [0.48, 1.06]
1 study · 1346 participants
Moderate

Dexamethasone vs betamethasone – maternal outcomes

Maternal puerperal sepsis · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs betamethasone – maternal outcomes

Maternal adverse effects of therapy · women at risk of preterm birth

Dexamethasone showed no clear difference in maternal adverse effects of therapy compared with betamethasone – maternal outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.63 [0.35, 1.13]
2 studies · 1705 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

Dexamethasone showed no clear difference in any known death after randomisation (fetal, neonatal, child, child… compared with betamethasone – fetal/neonatal outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 1.03 [0.66, 1.63]
5 studies · 2105 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Respiratory distress syndrome · women at risk of preterm birth

Dexamethasone showed no clear difference in respiratory distress syndrome compared with betamethasone – fetal/neonatal outcomes (high certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 1.06 [0.91, 1.22]
5 studies · 2105 participants
High

Dexamethasone vs betamethasone – child outcomes

Intraventricular haemorrhage · women at risk of preterm birth

Dexamethasone showed no clear difference in intraventricular haemorrhage compared with betamethasone – fetal/neonatal outcomes (low certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.71 [0.28, 1.81]
4 studies · 1901 participants
Low

Dexamethasone vs betamethasone – child outcomes

Chronic lung disease · women at risk of preterm birth

Dexamethasone showed no clear difference in chronic lung disease compared with betamethasone – fetal/neonatal outcomes (moderate certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 0.92 [0.64, 1.34]
1 study · 1509 participants
Moderate

Dexamethasone vs betamethasone – child outcomes

Necrotising enterocolitis · women at risk of preterm birth

Dexamethasone showed no clear difference in necrotising enterocolitis compared with betamethasone – fetal/neonatal outcomes (low certainty).

1 finding from 1 review

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth 2022 · Cochrane Headline outcomes only
RR 5.08 [0.25, 105.15]
2 studies · 441 participants
Low

Dexamethasone vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Dexamethasone showed no clear difference in incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (low certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
RR 0.6 [0.36, 1]
4 studies · 176 participants
Low