Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Oral Health

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Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome

Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…

A group of genera/species (notably Selenomonas, Aggregatibacter, Actinomyces, Treponema) was predictive of caries, whereas Streptococcus was not (ungraded).

1 finding from 1 review

Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes
Oral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive
19 studies · 2016 participants
GRADE not reported

Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome

Discrimination of caries vs health (random forest ROC-AUC) · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…

Microbiome-based random forest classifiers could not reliably discriminate caries from health across the combined cohort (best AUC approximately 0.75 in a disease-only KO subset; ungraded).

1 finding from 1 review

Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes
Oral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
AUC 0.75
19 studies · 2016 participants
GRADE not reported

Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome

Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples

In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded).

1 finding from 1 review

Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes
Oral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies · Adults
In adults, there was no significant caries-vs-health difference in Chao1 or Observed diversity, whereas the Shannon index differed significantly (p < 0.001).
Studies not reported
GRADE not reported

Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome

Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples

In children, caries-vs-health Shannon alpha diversity differed significantly (ungraded).

1 finding from 1 review

Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes
Oral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies · Children
In children, the Shannon alpha-diversity index differed significantly between caries and health (p < 0.001).
Studies not reported
GRADE not reported