Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

116 questions · 124 findings · 25 reviews · Infectious Diseases · Headline outcomes only

No studies found 7 · 5.6%GRADE not reported 6 · 4.8%Very low 24 · 19.4%Low 55 · 44.4%Moderate 21 · 16.9%High 11 · 8.9%

Primaquine five days vs 14 days

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

Primaquine five days probably leads to higher P. vivax parasitaemia detected > 30 days after starting primaquine compared with 14 days (moderate certainty).

1 finding from 1 review

Primaquine three days vs 14 days

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

Primaquine three days probably leads to higher P. vivax parasitaemia detected > 30 days after starting primaquine compared with 14 days (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with non‐artemisinin treatment

It is very uncertain whether single dose primaquine at 0.75 mg/kg changes participants infectious at day 5 compared with no primaquine, with non‐artemisinin partner, (very low certainty).

2 findings from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 5, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 5, by microscopy compared with no primaquine, with non‐artemisinin partner, (low certainty).

1 finding from 1 review

Favipiravir vs no treatment, supportive treatment, or other antiviral treatment

All‐cause mortality – at 28 to 30 days, or in‐hospital · people with confirmed COVID‐19

It is very uncertain whether favipiravir changes all‐cause mortality – at 28 to 30 days, or in‐hospital compared with no treatment, supportive treatment, or other antiviral treatment (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 28 · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The intervention may leads to lower all‐cause mortality at day 28 (low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at 14 days · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 28 · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

It is very uncertain whether the intervention changes all‐cause mortality at day 28 (very low certainty).

1 finding from 1 review

Intervention not reported

Quality of life up to 28 days and longest · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Viral clearance at 7 days · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

It is very uncertain whether the intervention changes viral clearance at 7 days (very low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at 14 days · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

It is very uncertain whether the intervention changes viral clearance at 14 days (very low certainty).

1 finding from 1 review