What do systematic reviews say?

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  Masuda 1989: multiple adverse events in the cyclosporin arm; 3 patients withdrew and 9 had a dose reduction as a result.
  1 study · 92 participants
  GRADE not reported

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) led to higher alleviation of oral aphthous ulcers compared with colchicine (systemic; 1 mg daily); GRADE not reported.

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes

  16 weeks
  RR 3.3 [1.85, 5.88]
  1 study · 92 participants
  GRADE not reported

Aciclovir (systemic; 800 mg 5x/day for 1 week then 400 mg 2x/day for 11 weeks) vs placebo

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  Davies 1988 (aciclovir vs placebo, 36 patients, cross-over; high risk of reporting bias; concomitant treatments): data were not presented in a usable format; authors reported no statistically significant difference in…
  1 study · 36 participants
  GRADE not reported

Sucralfate suspension (topical) vs Placebo suspension

Sucralfate suspension (topical) showed no clear difference in number of painful days compared with placebo suspension; GRADE not reported.

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes

  End of treatment
  MD 9.00 [-4.25, 22.25]
  1 study · 35 participants
  GRADE not reported

Dietary counselling tailored to a Stage of Change (Transtheoretical Model) to increase fruit and vegetable intake (two counselling sessions) vs usual care

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  6 weeks after receiving replacement dentures (about 10 weeks after baseline)
  Mean (SD) g/day (Table 1): fruit - intervention 111 (80) at baseline rising to 254 (194) at follow-up; control 87 (82) to 106 (116). A significant change in the weight of fruit consumed was found in the intervention…
  1 study · 58 participants
  GRADE not reported

Dietary counselling tailored to a Stage of Change (Transtheoretical Model) to increase fruit and vegetable intake (two counselling sessions) vs usual care

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  6 weeks after receiving replacement dentures (about 10 weeks after baseline)
  Mean (SD) g/day (Table 1): vegetables - intervention 157 (73) to 224 (109); control 168 (83) to 175 (91). No significant between-group change in vegetable consumption.
  1 study · 58 participants
  GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  2 to 4 years
  Table 2: 71% (178) versus 68% (168) at follow-up (baseline 69% versus 65%). No significant change.
  1 study · 497 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, mean (SD) intakes/day between meals: intervention 6.7 (1.9) baseline, 0.8 (1.0) at 3 weeks, 0.9 (1.0) at 6 weeks, 5.6 (3.0) at 12 weeks; control 5.3 (2.3), 5.2 (2.9), 4.6 (3.5), 4.7 (1.5). Significant…
  1 study · 20 participants
  GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  2 to 4 years
  Table 2: 77% (193) versus 81% (200) at follow-up (baseline 83% versus 74%, a significant baseline difference). No significant change at follow-up.
  1 study · 497 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, mean (SD) intakes/day at main meals: intervention 2.8 (0.5) baseline, 0.7 (0.7) at 3 weeks, 0.8 (0.9) at 6 weeks, 2.3 (0.8) at 12 weeks; control 1.9 (1.1), 1.9 (1.2), 1.9 (1.1), 2.0 (0.9). Significant…
  1 study · 20 participants
  GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Individually designed, patient-centred preventive programme: dietary… led to higher using xylitol products more than 3 times per day compared with basic prevention offered as standard in public dental clinics; GRADE not reported.

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  2 to 4 years
  RR 1.32 [1.04, 1.68]
  1 study · 497 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, total mean (SD) intakes/day: intervention 9.5 (1.9) baseline, 1.6 (1.4) at 3 weeks, 1.8 (1.5) at 6 weeks, 7.8 (3.5) at 12 weeks; control 7.2 (2.6), 7.1 (3.7), 6.5 (4.2), 6.7 (2.2). Significant reduction versus…
  1 study · 20 participants
  GRADE not reported