Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

135 questions · 145 findings · 44 reviews · Acute Respiratory Infections

No studies found 10 · 6.9%GRADE not reported 18 · 12.4%Very low 21 · 14.5%Low 54 · 37.2%Moderate 28 · 19.3%High 14 · 9.7%

Antibiotics vs placebo

Pain ‐ pain at 2 to 3 days · children with acute otitis media

Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 4 to 7 days · children with acute otitis media

Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 10 to 12 days · children with acute otitis media

Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).

1 finding from 1 review