Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Cysteamine vs no intervention

All‐cause mortality · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes mortality compared with no intervention (very low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
Peto OR 0.53 [0.05, 5.22]
2 studies · 65 participants
Very low

Cysteamine vs no intervention

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

Cysteamine may leads to lower hepatotoxicity (aspartate aminotransferase > 1000 IU/L) compared with no intervention (low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
OR 0.09 [0.02, 0.35]
2 studies · 65 participants
Low

Cysteamine vs dimercaprol

All‐cause mortality · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes mortality compared with dimercaprol (very low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
Peto OR 0.14 [0, 6.82]
1 study · 52 participants
Very low

Cysteamine vs dimercaprol

Mean maximum alanine aminotransferase (IU/L) · people with paracetamol (acetaminophen) overdose

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Low

Cysteamine vs methionine (randomised trials)

All‐cause mortality · people with paracetamol (acetaminophen) overdose

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Cysteamine vs methionine (randomised trials)

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
OR 0.92 [0.05, 16.46]
1 study · 27 participants
Very low