What do systematic reviews say?

Corticosteroids or ACTH vs placebo

Corticosteroids or ACTH probably leads to lower worse or unimproved within 5 weeks from randomisation compared with placebo (moderate certainty).

• Corticosteroids or ACTH for acute exacerbations in multiple sclerosis 2000 · Cochrane Headline outcomes only
  OR 0.37 [0.24, 0.57]
  5 studies · 330 participants
  Moderate

Corticosteroids or ACTH vs placebo

Corticosteroids or ACTH showed no clear difference in mean disability (EDSS) score—at 1 week after randomisation compared with placebo (moderate certainty).

• Corticosteroids or ACTH for acute exacerbations in multiple sclerosis 2000 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 62 participants
  Moderate

Corticosteroids or ACTH vs placebo

It is very uncertain whether corticosteroids or ACTH changes participants with new exacerbations during compared with placebo (very low certainty).

• Corticosteroids or ACTH for acute exacerbations in multiple sclerosis 2000 · Cochrane Headline outcomes only
  OR 1.72 [0.57, 5.19]
  1 study · 51 participants
  Very low

Intervention not reported

• Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 3 participants
  Low