Cochrane · systematic review · CD001331
Corticosteroids or ACTH for acute exacerbations in multiple sclerosis
Citterio, A, La Mantia, L, Ciucci, G, et al. · Cochrane Database of Systematic Reviews · 2000 · Cochrane Library
Multiple Sclerosis and Rare Diseases of the CNSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 2 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Corticosteroids or ACTH versus placebo for acute exacerbations in multiple sclerosis
Population: multiple sclerosis patients with acute exacerbations
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Worse or unimproved within 5 weeks from randomisation Corticosteroids or ACTH vs placebo | OR 0.37 [0.24, 0.57] | 5 studies · 330 participants | Moderate Downgraded: imprecision |
Mean disability (EDSS) score—at 1 week after randomisation Corticosteroids or ACTH vs placebo | no estimate extracted | 2 studies · 62 participants | Moderate Downgraded: imprecision |
Participants with new exacerbations during Corticosteroids or ACTH vs placebo | OR 1.72 [0.57, 5.19] | 1 study · 51 participants | Very low Downgraded: imprecision |