Findings

What do systematic reviews say?

93 questions · 94 findings · 11 reviews · Headline outcomes only

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No studies found 32 · 34%GRADE not reported 8 · 8.5%Very low 36 · 38.3%Low 13 · 13.8%Moderate 3 · 3.2%High 2 · 2.1%

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Amputation · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 164 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day mortality · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Vessel patency (up to 30 days) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs pulse spray technique

Patency at 30 days · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether continuous Infusion changes patency at 30 days compared with pulse spray technique (very low certainty).

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
RR 0.92 [0.67, 1.27]
1 study · 30 participants
Very low

Continuous infusion vs pulse spray technique

Failure · thrombosed haemodialysis arteriovenous fistulas and grafts

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs pulse spray technique

Technical success · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether continuous Infusion changes technical success compared with pulse spray technique (very low certainty).

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
RR 1.07 [0.89, 1.28]
1 study · 30 participants
Very low

Continuous infusion vs pulse spray technique

Access dysfunction · thrombosed haemodialysis arteriovenous fistulas and grafts

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs pulse spray technique

Successful dialysis · thrombosed haemodialysis arteriovenous fistulas and grafts

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs pulse spray technique

Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs pulse spray technique

Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether continuous Infusion changes minor adverse events compared with pulse spray technique (very low certainty).

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
RR 1 [0.07, 14.55]
1 study · 30 participants
Very low

Continuous infusion vs pulse spray technique

Death · thrombosed haemodialysis arteriovenous fistulas and grafts

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs bolus administration

Pain · postoperative pain in neonates

It is very uncertain whether continuous infusion changes pain compared with bolus administration (very low certainty).

2 findings from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
MD 0
2 studies · 133 participants
Very low
Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
MD 0.07
2 studies · 133 participants
Very low

Continuous infusion vs bolus administration

All‐cause mortality during initial hospitalization ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs bolus administration

Major neurodevelopmental disability in children aged 18 to 24 months or three to five years old ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs bolus administration

Cognitive and educational outcomes in children more than five years old ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs bolus administration

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found