Findings

What do systematic reviews say?

8 questions · 14 findings · 1 reviews · Periodontology · All outcomes

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No studies found 0 · 0%GRADE not reported 14 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Clarithromycin + SRP vs SRP

Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.65 [-1.20, -0.09]
2 studies · 77 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.64 [-1.26, -0.03]
2 studies · 77 participants
GRADE not reported

Clarithromycin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -4.70 [-8.42, -0.98]
1 study · 40 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -3.00 [-6.69, 0.69]
1 study · 40 participants
GRADE not reported

Clarithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Both included trials reported adverse events in the clarithromycin + SRP group: unpalatable taste and mild gastric intolerance in 2 patients (Pradeep 2011); mild gastrointestinal discomfort in 2 patients (Rebelatto…
Studies not reported
GRADE not reported

Clarithromycin + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.59 [-1.17, -0.01]
2 studies · 77 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.67 [-1.33, -0.01]
2 studies · 77 participants
GRADE not reported

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.00 [-0.26, 0.26]
1 study · 46 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.60 [-0.86, -0.34]
1 study · 46 participants
GRADE not reported

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Probing pocket depth · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.20 [-0.35, -0.05]
1 study · 46 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.10 [-0.26, 0.06]
1 study · 46 participants
GRADE not reported

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Adverse events · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Two patients were reported to have vomiting and unbearable stomach pain in the AMOX + MTZ + SRP group (Araujo 2019).
1 study
GRADE not reported

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 4.00 [-1.09, 9.09]
1 study · 46 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 5.40 [-0.12, 10.92]
1 study · 46 participants
GRADE not reported