Total nocturnal sleep time (minutes) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Difficulty waking in the morning, average of weeks 1 and 2№ of participants: 10(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Psychomotor vigilance task (PVT) reciprocal of reaction time, change from baseline№ of participants: 10(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Quality of life Functional Outcomes of Sleep Questionnaire · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Number of participants with any adverse events№ of participants: 10(1 RCT) · idiopathic hypersomnia
Clarithromycin showed no clear difference in number of participants with any adverse events№ of participants:… compared with placebo (low certainty).
1 finding from 1 review
OR 0.41 [0.01, 12.64]
Studies not reported
Low
Daytime sleepiness (ESS): change from baseline. · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Sleepiness · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea
The review found no eligible studies for this question.
1 finding from 1 review
Serious adverse events, i.e. serious enough to require withdrawal of the treatment · pityriasis rosea
1 finding from 1 review
The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea
Clarithromycin showed no clear difference in the proportion of participants with resolution of itch within 2… compared with placebo (moderate certainty).
1 finding from 1 review
Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea
The review found no eligible studies for this question.
1 finding from 1 review
The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea
Clarithromycin showed no clear difference in the proportion of participants with good or excellent rash… compared with placebo (moderate certainty).
1 finding from 1 review
Minor adverse events not leading to withdrawal of treatment · pityriasis rosea
The review found no eligible studies for this question.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
2 findings from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
2 findings from 1 review
Curea · people with Buruli ulcer, early lesions measuring less than 10 cm in diameter, aged 5 years or older
Rifampicin with clarithromycin showed no clear difference in curea compared with rifampicin with streptomycin (low certainty).
1 finding from 1 review
Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies
Systemic antibiotic (clarithromycin) showed no clear difference in oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review