Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Oral Health

No studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Clinical attachment level (CAL) · Adults with chronic periodontitis

Cefixime + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.19 [-0.77, 0.39]
1 study · 60 participants
GRADE not reported

Adverse events · Adults with chronic periodontitis

Cefixime + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
The only included trial (Dukic 2016) reported nausea, dizziness and/or anorexia in the cefixime + SRP group.
1 study · 60 participants
GRADE not reported

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Cefixime + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.48 [-0.60, -0.37]
1 study · 60 participants
GRADE not reported

Probing pocket depth · Adults with chronic periodontitis

Cefixime + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.02 [-0.11, 0.07]
1 study · 60 participants
GRADE not reported