What do systematic reviews say?

Intervention not reported

The intervention probably leads to higher at least 50% of maximum pain relief over 4 to 6 h (moderate certainty).

• Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
  RR 5.5 [3.5, 8.7]
  4 studies · 334 participants
  Moderate

Intervention not reported

The intervention probably leads to lower participants remedicating within 8 hours (moderate certainty).

• Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
  RR 0.5 [0.4, 0.6]
  3 studies · 293 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in participants with at least 1 adverse event (low certainty).

• Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
  RR 1.9 [0.91, 3.8]
  4 studies · 336 participants
  Low

Intervention not reported

• Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 336 participants
  Low

Intervention not reported

• Caffeine as an analgesic adjuvant for acute pain in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4262 participants
  High

Intervention not reported

• Caffeine as an analgesic adjuvant for acute pain in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low