Findings

What do systematic reviews say?

7 questions · 8 findings · 1 reviews · Breast Cancer · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 25%Low 3 · 37.5%Moderate 1 · 12.5%High 2 · 25%

Local recurrence · breast‐conserving radiotherapy for breast cancer

Boost may leads to lower local control: recurrence at 5 years compared with no boost (low certainty).

1 finding from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
HR 0.64 [0.55, 0.75]
5 studies · 8315 participants
Low

Overall survival: mortality at 5 years · breast‐conserving radiotherapy for breast cancer

Boost showed no clear difference in overall survival: mortality at 5 years compared with no boost (moderate certainty).

1 finding from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
HR 1.04 [0.94, 1.14]
2 studies · 6342 participants
Moderate

Disease-free survival (new disease, progression or mortality) · breast‐conserving radiotherapy for breast cancer

Boost showed no clear difference in disease‐free survival: disease progression/mortality at 5 years compared with no boost (low certainty).

1 finding from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
HR 0.94 [0.87, 1.02]
3 studies · 6549 participants
Low

Late toxicity, pBRA · breast‐conserving radiotherapy for breast cancer

It is very uncertain whether boost changes late toxicity, pBRA compared with no boost (very low certainty).

1 finding from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
MD 0.38
2 studies · 1526 participants
Very low

Cosmesis · breast‐conserving radiotherapy for breast cancer

Boost may leads to higher cosmesis, panel scored: fair or poor compared with no boost (low certainty).

2 findings from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
OR 1.41 [1.07, 1.85]
2 studies · 1116 participants
Low
Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
OR 1.58 [0.93, 2.69]
2 studies · 592 participants
Very low

Sensitivity analysis: local control ‐ recurrence at 5 years · breast‐conserving radiotherapy for breast cancer

Boost leads to lower sensitivity analysis: local control ‐ recurrence at 5 years compared with no boost (high certainty).

1 finding from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
HR 0.62 [0.52, 0.73]
3 studies · 6963 participants
High

Subgroup analysis: local control ‐ > 40 years old, recurrence at 5 years · breast‐conserving radiotherapy for breast cancer

Boost leads to lower subgroup analysis: local control ‐ > 40 years old, recurrence at 5… compared with no boost (high certainty).

1 finding from 1 review

Tumour bed boost radiotherapy for women after breast‐conserving surgery 2017 · Cochrane Headline outcomes only
HR 0.65 [0.53, 0.81]
2 studies · 5058 participants
High