Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Vascular · Headline outcomes only

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 5 · 71.4%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control · Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal (
  Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 176 participants
  Very low
Direct match · question page
- Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control · Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain (
  Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 176 participants
  Very low
Direct match · question page
- Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control · Increase in PFWD (m) (
  Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Low
Direct match · question page
- Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control · Incidence of amputation (
  Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
  RR 0.52 [0.27, 0.99]
  4 studies · 176 participants
  Very low
Direct match · question page
- Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control · All‐cause mortality (
  Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
  RR 1 [0.15, 6.63]
  3 studies · 123 participants
  Very low

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

All‐cause mortality ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes all‐cause mortality ( compared with control (very low certainty).

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
RR 1 [0.15, 6.63]
3 studies · 123 participants
Very low

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 176 participants
Very low

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Amputation · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes incidence of amputation ( compared with control (very low certainty).

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
RR 0.52 [0.27, 0.99]
4 studies · 176 participants
Very low

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Angiographic analysis · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

The review found no eligible studies for this question.

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 176 participants
Very low

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Increase in PFWD (m) ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 53 participants
Low

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Complications and side effects · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes side effects and complications ( compared with control (very low certainty).

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
RR 2.13 [0.5, 8.97]
4 studies · 176 participants
Very low