Findings

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Evidence found and GRADE certainty

78 questions · 78 findings · 13 reviews · Headline outcomes only

No studies found 10 · 12.8%GRADE not reported 2 · 2.6%Very low 26 · 33.3%Low 20 · 25.6%Moderate 12 · 15.4%High 8 · 10.3%

Bone marrow vs steroid injection

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · children with simple bone cysts

It is very uncertain whether bone marrow changes success rate (radiographically‐assessed healing of cyst healing… compared with steroid injections (very low certainty).

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

All‐cause mortality ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes all‐cause mortality ( compared with control (very low certainty).

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Amputation · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes incidence of amputation ( compared with control (very low certainty).

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Angiographic analysis · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

The review found no eligible studies for this question.

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Complications and side effects · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes side effects and complications ( compared with control (very low certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review