Bone metastases · women with early breast cancer
Bisphosphonates probably leads to lower bone metastases compared with placebo/observation (moderate certainty).
1 finding from 1 review
Infusion‐related events · women with early breast cancer
1 finding from 1 review
Bone metastases · women with advanced breast cancer without bone metastases
Bisphosphonates showed no clear difference in bone metastases compared with placebo/observation (moderate certainty).
1 finding from 1 review
Median time to a skeletal‐related event · women with advanced breast cancer without bone metastases
1 finding from 1 review
Overall survival · women with advanced breast cancer without bone metastases
Bisphosphonates showed no clear difference in overall survival compared with placebo/observation (high certainty).
1 finding from 1 review
Quality of life · women with advanced breast cancer without bone metastases
1 finding from 1 review
Skeletal‐related event (SRE) · women with metastatic breast cancer with bone metastases
Bisphosphonates leads to lower skeletal‐related event (SRE) compared with placebo/observation (high certainty).
1 finding from 1 review
Median time to a skeletal‐related event · women with metastatic breast cancer with bone metastases
1 finding from 1 review
Overall survival · women with metastatic breast cancer with bone metastases
Bisphosphonates showed no clear difference in overall survival compared with placebo/observation (moderate certainty).
1 finding from 1 review
Bone pain · women with metastatic breast cancer with bone metastases
1 finding from 1 review
Quality of life · women with metastatic breast cancer with bone metastases
1 finding from 1 review
Overall survival · women with early breast cancer
Bisphosphonates leads to lower overall survival compared with placebo/observation (high certainty).
1 finding from 1 review
Overall survival postmenopausal women · women with early breast cancer
Bisphosphonates leads to lower overall survival postmenopausal women compared with placebo/observation (high certainty).
1 finding from 1 review
Overall survival: pre‐ or perimenopausal women · women with early breast cancer
Bisphosphonates showed no clear difference in overall survival: pre‐ or perimenopausal women compared with placebo/observation (high certainty).
1 finding from 1 review
Disease‐free progression · women with early breast cancer
Bisphosphonates showed no clear difference in disease‐free progression compared with placebo/observation (high certainty).
1 finding from 1 review
Disease‐free progression: postmenopausal women · women with early breast cancer
Bisphosphonates leads to lower disease‐free progression: postmenopausal women compared with placebo/observation (high certainty).
1 finding from 1 review
Disease‐free progression: pre‐ or perimenopausal women · women with early breast cancer
Bisphosphonates showed no clear difference in disease‐free progression: pre‐ or perimenopausal women compared with placebo/observation (high certainty).
1 finding from 1 review
Incidence of fractures · women with early breast cancer
Bisphosphonates showed no clear difference in fracture incidence compared with placebo/observation (moderate certainty).
1 finding from 1 review
Adverse events: osteonecrosis of the jaw · women with early breast cancer
1 finding from 1 review