Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews · Dental caries · All outcomes

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Lower incisor inclination (lingual tipping and retrusion) · Children (approximately 11 years or older) with compromised mandibular first permanent molars

Bilateral lower first permanent molar extraction was associated with lingual tipping and retrusion of the lower incisors in one case-control study; ungraded.

1 finding from 1 review

Consequences of early extraction of compromised first permanent molar: a systematic review. 2018 All outcomes
Private clinics (Brazil)
Normando and Cavacami: lower incisor lingual tipping (1.NB mean 23.2 vs 28.4 degrees, P = 0.004) and retrusion (P = 0.03) after bilateral lower FPM loss. Table 3: Category III, Class C.
1 study
GRADE not reported

Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Skeletal development (occlusal plane rotation, facial height) · Children (approximately 11 years or older) with compromised mandibular first permanent molars

Bilateral lower first permanent molar extraction was associated with counter-clockwise rotation of the occlusal plane and a mild decrease in lower anterior face height in one case-control study; ungraded.

1 finding from 1 review

Consequences of early extraction of compromised first permanent molar: a systematic review. 2018 All outcomes
Private clinics (Brazil)
Normando and Cavacami: decreased GnSN angle (P = 0.05), counter-clockwise rotation of the occlusal plane (mean 5.6 vs 12.6 degrees, P = 0.0001), and decreased lower anterior face height (P = 0.048). Table 3: Category…
1 study
GRADE not reported

Unilateral cleft lip and palate (UCLP) vs Bilateral cleft lip and palate (BCLP)

Plaque · Patients with cleft lip and palate (CLP)

Plaque index does not differ significantly between unilateral and bilateral cleft lip and palate (MD -0.13, 95% CI -0.38 to 0.12; ungraded).

1 finding from 1 review

Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and… 2025 All outcomes
Clinical dental examination (Thailand and USA)
MD -0.13 [-0.38, 0.12]
2 studies · 117 participants
GRADE not reported

Unilateral extraction of the mandibular first permanent molar vs Bilateral extraction of the mandibular first permanent molars

Midline deviation of the mandibular arch · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found midline deviation more likely after unilateral than bilateral extraction (OR 11.6; single study; not GRADE-rated).

1 finding from 1 review

Spontaneous space closure after extraction of permanent first molars in children and adolescents: a systematic review… 2024 All outcomes
Until eruption of the permanent second molar (median follow-up 4.0 years) · University clinics and hospitals in 8 countries (children/adolescents <18 years) · Mandible
OR 11.6 [1.9, 70.3]
1 study
GRADE not reported