Clearance or reduction of antibody titres (N) · adults with both late‐stage, symptomatic Chagas disease and CCC
Benznidazole may leads to higher clearance or reduction of antibody titres (N) (a) at 12 months (b)… compared with placebo (low certainty).
1 finding from 1 review
Clearance of parasitaemia demonstrated by negative xenodiagnosis, blood culture, and/or molecular assays (N) · adults with both late‐stage, symptomatic Chagas disease and CCC
It is very uncertain whether benznidazole changes clearance of parasitaemia demonstrated by negative xenodiagnosis,… compared with placebo (very low certainty).
1 finding from 1 review
Pathological demonstration of tissue parasites (N) · adults with both late‐stage, symptomatic Chagas disease and CCC
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Clinical improvement (N) (a) Heart failure (b) Sustained ventricular tachycardia · adults with both late‐stage, symptomatic Chagas disease and CCC
Benznidazole showed no clear difference in clinical improvement (N) (a) Heart failure (b) Sustained ventricular… compared with placebo (low certainty).
1 finding from 1 review
Quality of life · adults with both late‐stage, symptomatic Chagas disease and CCC
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events (N) · adults with both late‐stage, symptomatic Chagas disease and CCC
Benznidazole probably leads to higher adverse events (N) compared with placebo (moderate certainty).
1 finding from 1 review
Intervention not reported
Positive PCR: RCT data ‐ benznidazole‐ Children PCR · people with chronic asymptomatic Trypanosoma cruzi infection
The intervention showed no clear difference in positive PCR: RCT data ‐ benznidazole‐ Children PCR (moderate certainty).
1 finding from 1 review
Intervention not reported
ECG Abnormalities ‐ RCT data ‐ benznidazole · people with chronic asymptomatic Trypanosoma cruzi infection
The intervention showed no clear difference in ECG Abnormalities ‐ RCT data ‐ benznidazole (low certainty).
1 finding from 1 review