Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Dental caries

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

MMP-8 expression/activity · Human carious dentin

MMP-8 may be increased before compared with after cavity sealing (very low certainty).

1 finding from 1 review

MMP-9 expression/activity · Human carious dentin

No difference in MMP-9 expression/activity was found before versus after cavity sealing (very low certainty).

1 finding from 1 review

MMP-2 expression/activity · Human carious dentin

No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty).

1 finding from 1 review

MMP-8 expression/activity · Human ex vivo carious dentin under sealed cavities

MMP-8 may be higher before than after cavity sealing, but the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Before vs after sealing (Kuhn 2016: 60 days follow-up) · Ex vivo (extracted teeth / clinical carious or biofilm samples)
MMP-8 may be increased in the dentin before when compared to dentin after cavity sealing; MMP-8 significantly reduced after 60 days of sealing (Kuhn et al., 2016; Chibinski et al., 2014).
2 studies · 48 participants
Very low

MMP-9 expression/activity · Human ex vivo carious dentin under sealed cavities

MMP-9 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Before vs after sealing (Kuhn 2016: 60 days follow-up) · Ex vivo (extracted teeth / clinical carious or biofilm samples)
There is no difference of MMP-9 expression/activity before and after cavity sealing, although the evidence is very uncertain.
2 studies · 48 participants
Very low

MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities

MMP-2 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Before vs after sealing (Kuhn 2016: 60 days follow-up) · Ex vivo (extracted teeth / clinical carious or biofilm samples)
There is no difference of MMP-2 expression/activity before and after cavity sealing, although the evidence is very uncertain.
2 studies · 48 participants
Very low