Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 25 findings · 3 reviews · Oral Health

No studies found 1 · 4%GRADE not reported 10 · 40%Very low 5 · 20%Low 2 · 8%Moderate 5 · 20%High 2 · 8%

Xylitol sucking tablets (1 g/day) vs no treatment

Number of infants with a caries increment · Infants/young children (primary teeth; baseline about 1 to 3 years)

Xylitol sucking tablets (1 g/day) showed no clear difference in number of infants with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review

Xylitol candy (7.5 g/day) vs Control (sorbitol) candy

Caries increment (dmfs, primary and permanent teeth combined) · Children (mixed dentition; baseline about 8 years)
1 finding from 1 review

Xylitol lozenges (4.7 g/day) vs no treatment

Number of children with a caries increment · Children (permanent teeth; baseline 8 to 10 years)

Xylitol lozenges (4.7 g/day) showed no clear difference in number of children with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
3 findings from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Dental caries: prevalence of root caries · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste probably leads to lower root caries at 36 months (Katz Root Caries Index) compared with fluoride toothpaste without triclosan (moderate certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Coronal caries increment · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in coronal caries increment at 30 to 36 months (decayed filled teeth,… compared with fluoride toothpaste without triclosan (high certainty).

2 findings from 1 review

Xylitol syrup (high dose, 8 g/day) vs Control (low-dose xylitol, 2.67 g/day) syrup

Adverse effects (loose stools, diarrhoea) · Infants (primary teeth; baseline about 9 to 15 months)
1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Plaque and gingivitis scores · Children and adolescents aged 16 years or less
1 finding from 1 review